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Selective Serotonin Reuptake Inhibitors

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Tag: Wellbutrin

Question:

I’m taking two Wellbutrin and one Prozac (20 mg.) each day.  Is there any reason he would have me taking them in combo?  What side effects can I expect?  Thanks for any help. Posted Via Uncensored-News.Com – Still Only $9.95 – http://www.uncensored-news.com       <><><><><><><>   The Worlds Uncensored News Source   <><><><><><><><>

Response:

> I’m taking two Wellbutrin and one Prozac (20 mg.) each day.  Is there > any reason he would have me taking them in combo?  What side effects > can I expect?  Thanks for any help.

One reason is that Prozac can have sexual side effects and Wellbutrin can help to counter that. Bruce.

Response:

Don’t know why for sure, but since both work on different neurotransmitters you might get more benefit.  I was on Paxil and later Zoloft (both in the same class as Prozac) and thought it was a good combo.  Also Wellbutrin helped with feeling tired.

– Hide quoted text — Show quoted text -> I’m taking two Wellbutrin and one Prozac (20 mg.) each day.  Is there > any reason he would have me taking them in combo?  What side effects > can I expect?  Thanks for any help. > One reason is that Prozac can have sexual side effects and Wellbutrin can > help to counter that. > Bruce.

Response:

>I’m taking two Wellbutrin and one Prozac (20 mg.) each day.  Is there >any reason he would have me taking them in combo?  What side effects >can I expect?  Thanks for any help.

It’s not entirely unreasonable. While I’m no fan of fluoxetine (Prozac), it does have benefits for many people and has been used with bupropion (Wellbutrin) for hard to treat cases. I’m currently on citalopram (Celexa) 20mg tid, bupropion (Wellbutrin) SR 150mg tid, as well as mood stabilisers. I haven’t had any problems with my med combinations, although like the saying goes, what works for me might not work for you. Darren.

Response:

>I’m taking two Wellbutrin and one Prozac (20 mg.) each day.  Is there >any reason he would have me taking them in combo?

SBN, I think the best person to ask is your  doctor.  The responses have all seemed reasonable, but no one here is a mind reader.  Only your doc knows why he prescribed it.  And it is always good to ask a doc, any doc, why they are prescribing something – what is it supposed to do; how long is going to take before you see an effect; any side effects you should look for and which ones should be contact him about immediately and which ones can hold off until the next visit; etc. Good luck, Cathy Postcard Pals: http://www.geocities.com/mensan_Cathy Affective Friends: http://www.geocities.com/postcard_Cathy Kutsher’s Camp Anawana: http://www.geocities.com/kutsherscampanawana Hewlett High School: http://www.geocities.com/hewlettalumni

Response:

Question:

Prozac Truth How to taper off medication   Quitting ssris and psychiatric medication must be done by tapering off, very slowly. Step by step instructions found on this Web Site.   How to Taper Off Prozac, Sarafem, Paxil, Celexa, Zoloft, Wellbutrin and other Psychiatric Medication Read testimonials of people that have quit psychiatric medication with this method. Click Here (This page also includes recent feedback from people tapering off medication with this method) I want to hear from you. If you are using this method or not, it does help to have someone to talk with during withdrawal. Click Here to send e-mail. A change in your diet can make a change in how you feel. Click here to visit a common sense Web Site by, Dr. Hugh Mann, M.D. If you plan to change your diet while tapering, do so mildly. If you smoke or drink coffee, first taper off the medication before you quit. Your metabolism plays a major role during tapering and detox. Take the time to read Dr. Mann’s information. How to Taper Step-by-Step Recommendation Click the text below that applies to you situation: Currently using medication and have not reduced the dosage yet Currently using medication and have already started to taper You have already quit taking medication but are suffering from side effects Currently using medication and have not reduced the dosage yet Inform your doctor you wish to discontinue the medication Begin replenishing the intracellular glutathione levels in the body. This needs to be done before you begin to taper. a) Begin by increasing intracellular levels of glutathione for at least one full week before beginning the taper. Longer if necessary. I have received information from a physician that he is having people stay at this step for 8 weeks before tapering. Each individual is different. I do not feel that an arbitrary amount of time on this step is warranted. What has shown to be the most effective is staying on this step for at least one full week or until most of your side effects are gone or nearly gone AND YOU FEEL VERY STABLE. You should not begin to taper off the medication until all or nearly all of your current side effects are gone. Getting yourself very stable before tapering is critical. If you are getting the

Question:

I have a hypomanic reaction to SSRIs. Is there anything out there that doesn’t lead to hypomania in those of us that are prone toward it? Louise

Response:

> I have a hypomanic reaction to SSRIs. > Is there anything out there that doesn’t lead to hypomania in those of > us that are prone toward it? > Louise

I have the same problem with SSRI and tried Serzone (no hypomanic reaction but made me sleep all the time) and Manerix (moclobemide), a good antidepressant with very little side effects that is not available in the US. alias.p

Response:

> I have a hypomanic reaction to SSRIs. > Is there anything out there that doesn’t lead to hypomania in those of > us that are prone toward it? > Louise

I understand that the new direction of anti-depressants, after patents expire soon such as on prozac, will actually be a backwards direction, towards tricyclics. You might explore those, and also consider that wellburtin (is supposed to) effects dopamine rather than seratonin. I believe wellbutrin is more commonly prescribed to patients who might experience (hypo)mania. You also need to discuss these things with your doctor.

Response:

That’s odd since Wellbutrin is definitely one of the speediest of current ADs, often causing insomnia in fact.

Response:

> That’s odd since Wellbutrin is definitely one of the speediest of current ADs, > often causing insomnia in fact.

What’s even more odd, is that neurontin is used as a mood stabilizer, yet causes almost immediate hypomania. They might use it as an anti depressant now, I’m not sure.

Response:

– Hide quoted text — Show quoted text -> I have a hypomanic reaction to SSRIs. > Is there anything out there that doesn’t lead to hypomania in those of > us that are prone toward it? > Louise > I understand that the new direction of anti-depressants, after patents > expire soon such as on prozac, will actually be a backwards direction, > towards tricyclics. You might explore those, and also consider that > wellburtin (is supposed to) effects dopamine rather than seratonin. I > believe wellbutrin is more commonly prescribed to patients who might > experience (hypo)mania. > You also need to discuss these things with your doctor.

I took Wellbutrin a while ago and was so-o-o-o irritable I couldn’t stand myself! Louise

Response:

Question:

I would welcome any other input about my case. I know eric’s mind along with D. Diamond. Thanks Just really scared about the incurable side effects of the schizo drugs even in low doses My fear of germs has escalated since starting/raising the Wellbutrin SR. Just feel the need to wash intensely (lather up) and be concious of what I touch and who I touch. Need to wash clothes in hot water. Don’t like to touch anything before eating (after washing). Excessive doubt as to the cleanliness of things, spoons plates, etc.Feel the need to go the extra mile and then some to placate my worry. On vacation last week in Mexico and out of the house, I am OK and just deal with what I have available. Home life is the target of my obsession. Related is my inability to think clearly about things. Memory fuzzy, foggy thinking, spend lots of mental effort to make qualitative and quantitative decisions. Don’t "know" things. What does come thru loud and clear is my worry about the germs. I know intellectually that germs are good to some degree and that I don’;t live with plague patients either. Just have much heightened anxiety about the germs. Doc has suggested Risperdal along with mylow dose of Zoloft, as way to help my depression and help OCD. I don’t like the side effect of TD though. I have not read too favorable reports from netizens about these drugs. Mostly it seems these anxieties are pronounced and require my increased vigilence. I don’t wash 25 times in a row or check the stove over and over. Rather I am on alert all of the time to subtle possibilities of germs and then excessively try to prevent infection/contamination. When and if germs are encountered I get upset but only temporarily ? I am not sure. Other options are Buspar or switch SSRI I guess. Help

Response:

- Hide quoted text — Show quoted text – > I would welcome any other input about my case. I know eric’s mind > along with D. Diamond. Thanks > Just really scared about the incurable side effects of the schizo > drugs even in low doses > My fear of germs has escalated since starting/raising the Wellbutrin > SR. Just feel the need to wash intensely (lather up) and be concious > of what I touch and who I touch. Need to wash clothes in hot water. > Don’t like to touch anything before eating (after washing). Excessive > doubt as to the cleanliness of things, spoons plates, etc.Feel the > need to go the extra mile and then some to placate my worry. On > vacation last week in Mexico and out of the house, I am OK and just > deal with what I have available. Home life is the target of my > obsession. Related is my inability to think clearly about things. > Memory fuzzy, foggy thinking, spend lots of mental effort to make > qualitative and quantitative decisions. Don’t "know" things. What does > come thru loud and clear is my worry about the germs. I know > intellectually that germs are good to some degree and that I don’;t > live with plague patients either. Just have much heightened anxiety > about the germs. > Doc has suggested Risperdal along with mylow dose of Zoloft, as way to > help my depression and help OCD. I don’t like the side effect of TD > though. I have not read too favorable reports from netizens about > these drugs. Mostly it seems these anxieties are pronounced and > require my increased vigilence. I don’t wash 25 times in a row or > check the stove over and over. Rather I am on alert all of the time to > subtle possibilities of germs and then excessively try to prevent > infection/contamination. When and if germs are encountered I get upset > but only temporarily ? I am not sure. > Other options are Buspar or switch SSRI I guess. > Help

Hi Al, I can give you a little input, though I confess I don’t know the right drugs for you; hypochondria is often a sign of anxiety and depression.  Wellbutrin increases anxiety as an AD, so if I were to choose an AD, I would choose something more sedating, either SSRI or otherwise depending on how you tolerate them. Squiggles

Response:

>Doc has suggested Risperdal along with mylow dose of Zoloft, as way to >help my depression and help OCD. I don’t like the side effect of TD >though. I have not read too favorable reports from netizens about >these drugs. Mostly it seems these anxieties are pronounced and >require my increased vigilence. I don’t wash 25 times in a row or >check the stove over and over. Rather I am on alert all of the time to >subtle possibilities of germs and then excessively try to prevent >infection/contamination. When and if germs are encountered I get upset >but only temporarily ? I am not sure.

You should give Risperdal a try.  I went through an incredibly manic germ freak phase several years ago after my brother tested HIV+.  I completely lost it and sprayed alcohol, ammonia, and bleach on everything my brother may have touched.  Since then I have been on Risperdal and Seroquel and he just came to visit for xmas.  I handled it surprisingly well, although I absolutely refused to let him use my bathroom. By the way, a germ phobia isn’t necessarily so bad.  In April 2000 I took a trip to Oaxaca, Mexico and hooked up with a cool local who scored me some marijuana.  As is the druggie custom, I smoked several joints with him.  We crashed in his shack and when he began snoring I realized he had a serious respiratory infection.  3 days later I was in Mexico City and sick as a dog.  I could barely move.  I went to a pharmacy and bought tetracycline and erythromycin.  They worked very well but gave me diahrrea and ruined the rest of my trip. Moral of story:  germ phobia can be a good thing, don’t share drugs with anyone!

Response:

Hi Al, First of all, I am no doc.  I have experience cause of my depression all of my life, and my thirty year old son who lives with me has delusions so badly that if he is not on his antipsychotic med, he cannot work, or function. He doesn’t have your experience of germ stuff, but he has his own……. of fearing that someone is "out to get him". It is so traumatic for him, and family of course.  Once he gets stabilized, he is fine. Now that you say that you have this germ fear, I do suggest an antipsychotic, whichever one your doc suggests.  My son is on zyprexa, depacote, etc.  It works for him. When you first posted you did not mention your germ fear.  All I have to give you is my life experience and altho I do have my depression that renders me disfunctional a lot, I have never had any fears such as yours or my sons.  I believe it is referred to as delusional. Give your doc a chance and go for the med that will calm your mind. Obsession about anything can be so disturbing.  Years ago there were no drugs (not so long ago….thirty to be exact cause I was in therapy then, and my pdoc kept telling me there are no pills that would help me)  for you, or me, and now that there are, we might as well relieve our mental pain.  Post again to let us know how you are doing and what you are doing.  Deb

Response:

Hi, – Hide quoted text — Show quoted text -> I would welcome any other input about my case. I know eric’s mind > along with D. Diamond. Thanks > Just really scared about the incurable side effects of the schizo > drugs even in low doses > My fear of germs has escalated since starting/raising the Wellbutrin > SR. Just feel the need to wash intensely (lather up) and be concious > of what I touch and who I touch. Need to wash clothes in hot water. > Don’t like to touch anything before eating (after washing). Excessive > doubt as to the cleanliness of things, spoons plates, etc.Feel the > need to go the extra mile and then some to placate my worry. On > vacation last week in Mexico and out of the house, I am OK and just > deal with what I have available. Home life is the target of my > obsession. Related is my inability to think clearly about things. > Memory fuzzy, foggy thinking, spend lots of mental effort to make > qualitative and quantitative decisions. Don’t "know" things. What does > come thru loud and clear is my worry about the germs. I know > intellectually that germs are good to some degree and that I don’;t > live with plague patients either. Just have much heightened anxiety > about the germs.

Is your doctor aware of this since the AD was increased? > Doc has suggested Risperdal along with mylow dose of Zoloft, as way to > help my depression and help OCD. I don’t like the side effect of TD > though. I have not read too favorable reports from netizens about > these drugs. Mostly it seems these anxieties are pronounced and > require my increased vigilence. I don’t wash 25 times in a row or > check the stove over and over. Rather I am on alert all of the time to > subtle possibilities of germs and then excessively try to prevent > infection/contamination. When and if germs are encountered I get upset > but only temporarily ? I am not sure.

TD can occur but at low does it in not very likely. The newer APs have a lower incidence of TD. The treatment of OCD involves cognitive behavior therapy (CBT) alone or with a combination of CBT and medication  and SSRIs. Clomid is an OCD drug which is not an SSRI. The likelihood that medication will be included depends on  the severity of the OCD and the age of the patient. In milder OCD, CBT alone is the initial choice. As severity increases, medications  will likely be added to CBT as the initial treatment or to use medication alone. – Hide quoted text — Show quoted text –

Response:

<snip> First of all, does your doctor know about the increase in your OCD since starting Wellbutrin? If not, make sure you tell her/him right away. Second, I’ve found Seroquel very useful for my own somewhat obsessive thought problems, but I don’t qualify for an OCD diagnosis and my problems are all thought-related. Third, while there is a risk of TD and movement disorders with anti-psychotics, sometimes the risk is worth the result. Fiona — If we had no winter, the spring would not be so pleasant: if we did not sometimes taste the adversity, prosperity would not be so welcome.      – Anne Bradstreet, Meditations Divine and Moral, 1664

Response:

> ECT is safer than taking neuroleptics.

Leaving aside the accuracy of this statement, is ECT usually indicated for someone with high anxiety and OCD? No point in doing ECT if it’s not likely to help. Fiona — If we had no winter, the spring would not be so pleasant: if we did not sometimes taste the adversity, prosperity would not be so welcome.      – Anne Bradstreet, Meditations Divine and Moral, 1664

Response:

> It IS an accurate statement Fiona. If your primary diagnosis is a MOOD DISORDER > and not a PERCEPTION or psychotic disorder like schizophrenia, ECT is actually > safer in the long run than taking anti-psychotic drugs.

But this person is saying that her/his primary problems are anxiety and OCD, not a mood disorder. None of what you’ve written addresses the question of whether or not ECT is a useful or recommended treatment for someone with severe anxiety and OCD. Fiona — If we had no winter, the spring would not be so pleasant: if we did not sometimes taste the adversity, prosperity would not be so welcome.      – Anne Bradstreet, Meditations Divine and Moral, 1664

Response:

- Hide quoted text — Show quoted text ->Leaving aside the accuracy of this statement, is ECT usually indicated >for someone with high anxiety and OCD? No point in doing ECT if it’s not >likely to help. >Fiona >– >If we had no winter, the spring would not be so pleasant: if we did not >sometimes taste the adversity, prosperity would not be so welcome. >    – Anne Bradstreet, Meditations Divine and Moral, 1664 > It IS an accurate statement Fiona. If your primary diagnosis is a MOOD DISORDER > and not a PERCEPTION or psychotic disorder like schizophrenia, ECT is actually > safer in the long run than taking anti-psychotic drugs. > ECT doesnt cause movement disorders…period. The worst side effect from ECT > usually is memory loss.

Usually, perhaps but sometimes the side effects go so much further. Going to play Russian Roulette with YOUR brain?  Longterm anti-psychotics for someone who is primarily > MOOD DISORDERED is bad ju ju. Your destroying your dopamine system. People who > have unipolar major depression dont normally have high dopamine levels like > schizophrenics do to start out with, so someone whose main dx is major > depression taking neuroleptics is potentially screwing with their dopamine > system…which is VITAL for movement and locomotion, breathing, motor skills > like driving your car or writing or typing all kinds of physical things you > take for granted and dont even think about. > ECT also helps psychosis…its well documented for that.

Actually not, just a few studies based upon a review of records.  ECT is indicated for depression, or when the Psychiatrist can not think of anything else. – Hide quoted text — Show quoted text -> I wish I had never touched a neuroleptic. Atypicals is when I become med > resistant years ago and recently when I retried an atypical it fucked me all up > even worse. > I think atypical anti-psychotics for major depression, "rumination" and > "obsessive thoughts" is bullshit. Its just crappola the pharmaceutical > companies invented so they could sell more of their atypical > antidepressants…expand their marketing and sales to depression and not just > schizo people. Id rather just take antidepressants or go get shocked. > Many severe depressives need MORE dopamine, not less dopamine. Just look at the > effectiveness of the MAOIs…they are all extremely dopaminergic > antidepressants. Also, one of the historically most effective antidepressants > for severe depression was a potent dopaminergic antidepressant called > nomifensine. It was pulled off the market after it was here in the USA by the > FDA officially cause it was said nomifensine could cause a "rare blood > disorder." The rumor though is that it was really pulled cause the FDA thought > it was too dopaminergic. > One of the main theories of "SSRI poopout" is dopamine depletion. SSRIs and > similar meds deplete dopamine levels when taken longterm, potentially causing > "poopout" and loss of effectiveness. > And some of these fucking doctors want to put TRDepressives on atypical > antipsychotics? LOL Some of them need MORE dopamine, not less of it. > But the drug companies are scared to go there and develop dopaminergic > antidepressants, because dopamine is associated with addiction and psychosis > too much. But the reality is that some of us with depression NEED more > dopamine. > ECT increases dopamine, anti-psychotics decreases dopamine. Thats why ECT has > off label uses for treating parkinsons disease and movement disorders…even > TD.  Thats a hard fact…look it up yourself on Medline. > Its the war on drugs. Its bullshit. > Eric > "Who Dares, Wins" <motto of ECT patients> > http://groups.yahoo.com/group/MergePsychiatryIntoNeurology/

Response:

> <snip> > First of all, does your doctor know about the increase in your OCD since > starting Wellbutrin? If not, make sure you tell her/him right away. > Second, I’ve found Seroquel very useful for my own somewhat obsessive > thought problems, but I don’t qualify for an OCD diagnosis and my > problems are all thought-related. > Third, while there is a risk of TD and movement disorders with > anti-psychotics, sometimes the risk is worth the result. > Fiona

Yes he knows about the OCD and we are lowering with some better results. Clearer thinking, less compulsion. BTW, whats the difference between "thought related disorders" and OCD ? Also, Anyone have input about Buspar ????

Response:

> Yes he knows about the OCD and we are lowering with some better > results. Clearer thinking, less compulsion.

Glad to hear it. > BTW, whats the difference between "thought related disorders" and OCD?

I don’t have a compulsion to do anything. I have certain repetitive trains of thought, once the train is started I have a hard time stopping the cycle from completing. These thoughts can be obsessive on my part, but I don’t have any kind of compulsion to have the thoughts or (thank the Lady) to act on them. It’s akin to rolling a rock downhill, once you’ve started the rock it will keep rolling to the bottom unless something intervenes. For me, Seroquel provides some of that intervention, enough so that I (and my therapist) can stop the rock. One of the reasons that this is a problem is that these cycles are nearly all about killing myself, and I tend to get a little closer to actually trying every time I go all the way down the hill. It also provides a little buffer against my perfectionism and its related anxiety. > Also, Anyone have input about Buspar ????

Sorry, can’t help you there. Fiona — If we had no winter, the spring would not be so pleasant: if we did not sometimes taste the adversity, prosperity would not be so welcome.      – Anne Bradstreet, Meditations Divine and Moral, 1664

Response:

Question:

Even though the package insert for Prozac and the Physicians Desk Reference list no sexual side effects for Prozac when taken for depression, a review of the current literature will tell you that from 40 to 80 per cent of patients expereience sexual dysfunction with the SSRI’s.  For me, Prozac has caused a drastic reduction on libido, an inability to sustain an erection, difficulty in achieving orgasm and much less pleasurable sensation.   My psychiatrist recommended cutting the dosage of Prozac in half to 10 mg.day. This did not help. In fact, I had a relapse and went back to 20 mg a day of Prozac.   He is now recommending adding 75 mg of Wellbutrin SR per day to augment the Prozac and hopefuly relieve the sexual dysfunction.  I would really appretiate anyone who has taken this combination letting me know if it worked to reverse the sexual dusfunction.  Also, I take 3 to 4 mg of Xanax a day to alleviate the anxiety caused by the Prozac, and am therefore concerned about any increased agitation caused by the addition of the Wellbutrin. My psychiatrist said I was too concerned about increased agitation;  he stated I could simply increase the dosage of Xanax.  However, he did no realize I was taking 3 to 4 mg a day of Xanax.  He had thought I was taking three to 4 0.25 mg tablets a day rather than 3 to 4 mg even though he wrote the prescription.  He said he had failed to check my chart when he approved the increase from 3 to 4 mg per day when I told him that I was having a relapse. Note:  I had *no* sexual dysfuntion and minimal anxiety problems prior to taking Prozac.  My depression had no effect on these areas. Also, interested in any other solutions people have attempted and their results;  ie.: Switching to Serzone or augmenting an SSRI with Serzone Switching to Remeon or augmenting an SSRI with Remeron (My psychiatrist did not recommend Remeron because he said it was too new and caused excessive sedation, more so than Serzone). Really appreciate some real life expereiences and not just material read from medical journals.  Thanks!!!

Response:

> (My psychiatrist did not recommend Remeron because he said it was too > new and caused excessive sedation, more so than Serzone). > Really appreciate some real life expereiences and not just material > read from medical journals.  Thanks!!!

That’s true about Remeron.  It makes people fat too.   I’d suggest getting off Xanax – it’s a benzodiazepine, and they’re addictive. Gingko biloba tablets may help with the sexual dysfunction side: www.sexual-enhancement-gingko.com   A sugary meal/drink may help.

Response:

http://www.sexual-enhancement-gingko.com/sexual-enhancement.htm There is general agreement of a low risk associated with Ginkgo extract products. In one study , gingko biloba by itself, improved erectile dysfunction in a group of impotent males after six months of use. The discovery of Ginkgo biloba extract’s (GBE) ability to reverse antidepressant-induced sexual dysfunction was reported in patients studied over a 6-8 week period. Five patients treated for DSM-IV diagnosis of Depression with an SSRI (fluoxetine or sertraline) developed sexual dysfunction during the course of their treatment. The three men in the study reported anorgasmia, decreased libido, and erectile failure. The two women had anorgasmia, delayed orgasm and decreased libido. Each patient was started on a course of GBE 60 mg. (50:1 extract) twice a day. In another study, each patient chose to continue the treatment for an open ended period with clinical monitoring of symptoms. Three patients described brief periods of discontinuation of the GBE with a concomitant return of the ASD. The male patients,ages 45, 42, and 38, each had a single episode of non- psychotic major depression. The women, 48 and 49, had recurrent, unipolar depression, non-psychotic. Both women also had Hashimoto’s thyroiditis. Their thyroid indices were normal on replacement T-4. There were no other medical conditions, nor substance abuse problems. Adverse reactions to the GBE were minimal and did not disrupt the treatment. Some gastro-intestinal complaints and lightheadedness were reported. No abnormal bleeding nor bruising occurred.

Response:

i tried just about all the usuall treatments for sexual dysfuntion and nothing worked.   cyproheptadine,  stimulants and so on did nothing. very low dose zoloft worked but it might not be enough to treat your depression. i found with the effexor tablets i could get a few hours a day of normal sexual function before having to take the days dosage. i eventually just gave up – Hide quoted text — Show quoted text – >Even though the package insert for Prozac and the Physicians Desk >Reference list no sexual side effects for Prozac when taken for >depression, a review of the current literature will tell you that from >40 to 80 per cent of patients expereience sexual dysfunction with the >SSRI’s.  For me, Prozac has caused a drastic reduction on libido, an >inability to sustain an erection, difficulty in achieving orgasm and >much less pleasurable sensation.   >My psychiatrist recommended cutting the dosage of Prozac in half to 10 >mg.day. This did not help. In fact, I had a relapse and went back to >20 mg a day of Prozac.   He is now recommending adding 75 mg of >Wellbutrin SR per day to augment the Prozac and hopefuly relieve the >sexual dysfunction.  I would really appretiate anyone who has taken >this combination letting me know if it worked to reverse the sexual >dusfunction.  Also, I take 3 to 4 mg of Xanax a day to alleviate the >anxiety caused by the Prozac, and am therefore concerned about any >increased agitation caused by the addition of the Wellbutrin. My >psychiatrist said I was too concerned about increased agitation;  he >stated I could simply increase the dosage of Xanax.  However, he did >no realize I was taking 3 to 4 mg a day of Xanax.  He had thought I >was taking three to 4 0.25 mg tablets a day rather than 3 to 4 mg even >though he wrote the prescription.  He said he had failed to check my >chart when he approved the increase from 3 to 4 mg per day when I told >him that I was having a relapse. >Note:  I had *no* sexual dysfuntion and minimal anxiety problems prior >to taking Prozac.  My depression had no effect on these areas. >Also, interested in any other solutions people have attempted and >their results;  ie.: >Switching to Serzone or augmenting an SSRI with Serzone >Switching to Remeon or augmenting an SSRI with Remeron >(My psychiatrist did not recommend Remeron because he said it was too >new and caused excessive sedation, more so than Serzone). >Really appreciate some real life expereiences and not just material >read from medical journals.  Thanks!!!

Response:

Question:

Now that I am coming off effexor xr and it will take some time I think…..now its time to think of what med to change to….quickly my hang-ups…..worrier….anxiety….very high pressure job…..a mind that never stops thinking…..endless self analysis…always taken though responsibility for things that are out of my control….these are just to start with.. once I was on top of the world……now I look up…..

Response:

> Now that I am coming off effexor xr and it will take some time I > think…..now its time to think of what med to change to….quickly my > hang-ups…..worrier….anxiety….very high pressure job…..a mind that > never stops thinking…..endless self analysis…always taken though > responsibility for things that are out of my control….these are just to > start with.. > once I was on top of the world……now I look up…..

And a bird craps on your head, right?  LOL  Couldn’t resist.  Is it just human nature to experience what you’ve described above?  Or, is it all part of depression?  I’m kicking Wellbutrin.  I have nowhere to go now.  I’m so tired of the side effects, I’m just like an old, wet, rung out, worn out dish rag.  I’ve used Effexor XR 2 years ago and a number of others.  Have you tried Wellbutrin, Paxil or any others? Cheers, Carrie

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I’m curious as to why we go off meds…..do they cease to stop the depression?    I just stopped effexor and went straight to Remeron…..I’ve never been advised of weaning off one to begin another, although my research into these things would suggest that I do wean off. The Remeron made me totally undepressed for two days, but the past two days I’m on edge…..much the same way I felt with Effexor and Celexa. I am going to post a new thread re xanax. Jeanne

– Hide quoted text — Show quoted text -> Now that I am coming off effexor xr and it will take some time I > think…..now its time to think of what med to change to….quickly my > hang-ups…..worrier….anxiety….very high pressure job…..a mind that > never stops thinking…..endless self analysis…always taken though > responsibility for things that are out of my control….these are just to > start with.. > once I was on top of the world……now I look up….. > And a bird craps on your head, right?  LOL  Couldn’t resist.  Is it just > human nature to experience what you’ve described above?  Or, is it all part > of depression?  I’m kicking Wellbutrin.  I have nowhere to go now.  I’m so > tired of the side effects, I’m just like an old, wet, rung out, worn out > dish rag.  I’ve used Effexor XR 2 years ago and a number of others.  Have > you tried Wellbutrin, Paxil or any others? > Cheers, Carrie

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i have just gone back on meds, and started with the ZOLOFT sample pack of i am also VERY TIRED of this "on again, off again" — read and post daily! rosie http://www.geocities.com/barrettetc/rosie.html

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I came over to this group today (have been at alt.support. depression.recovery for awhile) because I’m facing the possibility of accepting some anti-depressant prescription later this week.  I’ve been in something I’ve called an "anxiety crisis" since last Sept., more recently getting some of the anxiety under control, and being told, by therapist, that I’m now experiencing depression.  I keep telling myself that I "should" be able to overcome this problem… through therapy, altered self-talk, disphragmatic breathing, and other techniques. Strong resistance to going on medication (though I did accept and try some Xanax during part of this time period, but didn’t notice any success with it).  I think my docotor is ready to prescribe Paxil or something like that. I resist partly due to concerns about money (which helped trigger this "anxiety crisis"), and partly because I don’t want to have to rely on chemistry to affect my moods.  One option might be to accept prescription for some milder (?)[and cheaper?] medications.  Someone suggested Elavil?, and one of the drugs you’ve been discussing here.  Effexor, I think? I’m interested in some informed opinions.  My own depression doesn’t seem so severe as some of the people I encounter here. My mornings are usually "bad", waking up at five a.m., and not being able to get back to sleep.  But many days I manage to make myself DO things, and sometimes wind up later in the day with feeling O.K. (mostly, when I’m NOT "O.K.", I think I’m in "fight or flight" response.  Then.. due to some new thought, or a different activity?, etc.?, I can suddenly find myself feeling "relief".  It’s like the tension which has been strangling me is suddenly gone… and I can be relaxed for awhile.  I’m trying to learn some techniques… so that I can create that relaxation to some extent on demand.  Currently I feel like a victim of my moods.  I’d like to have some power over them. Do some of the drugs have this effect?  Could medication give me some control?  If so… what might you recommend? thanks for any suggestions… dennis

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Actually it was very funny cuz my bird actually did do that! lol Yes all things I listed below could be just describing life but its life that has put the screws to me….see when you usually sit across the table(I am a social worker) and work out other people’s troubles you don’t always see it that way….every day I wake I never know what emotion or person I will be today. Since I have to where the painted face all day at work it makes it hard to do it at home. After my time as a work aholic for many years I now know that my time is deserved to my family. I just wish I could give then stability in my personality. Admitting that I needed help was the hardest thing I have ever done. See I know I have not been "right" ever since childhood. No blame to anyone Unfortunately there are no family dr’s around my area so I am stuck with the walk in clinic. The last dr recommended that I drop effexor xr and try Paxil. I am not sure what to think?????

– Hide quoted text — Show quoted text -> Now that I am coming off effexor xr and it will take some time I > think…..now its time to think of what med to change to….quickly my > hang-ups…..worrier….anxiety….very high pressure job…..a mind that > never stops thinking…..endless self analysis…always taken though > responsibility for things that are out of my control….these are just to > start with.. > once I was on top of the world……now I look up….. > And a bird craps on your head, right?  LOL  Couldn’t resist.  Is it just > human nature to experience what you’ve described above?  Or, is it all part > of depression?  I’m kicking Wellbutrin.  I have nowhere to go now.  I’m so > tired of the side effects, I’m just like an old, wet, rung out, worn out > dish rag.  I’ve used Effexor XR 2 years ago and a number of others.  Have > you tried Wellbutrin, Paxil or any others? > Cheers, Carrie

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(snip). – Hide quoted text — Show quoted text -> Yes you dont sound that bad…this NG tends to attract people with more severe > mental illness problems, including a lot with whats known as "treatment > resistant" depression. >My mornings are usually "bad", waking up at five a.m., >and not > being able to get back to sleep.  But many days I manage to > make myself DO things, and sometimes wind up later in the day > with feeling O.K. (mostly, when I’m NOT "O.K.", I think I’m > in "fight or flight" response.  Then.. due to some new thought, > or a different activity?, etc.?, I can suddenly find myself > feeling "relief".  It’s like the tension which has been strangling > me is suddenly gone… and I can be relaxed for awhile.  I’m > trying to learn some techniques… so that I can create that > relaxation to some extent on demand.  Currently I feel like a > victim of my moods.  I’d like to have some power over them. > Do some of the drugs have this effect?  Could medication give me > some control?  If so… what might you recommend? > thanks for any suggestions… dennis > You sound like youd be a perfect candidate for drugs Dennis. Your attitudes > against meds are silly. The meds can help you. The modern class meds in > particular are very safe to take, they really are very safe. The older psych > meds tended to have a lot more side effects and people many times didnt like > taking them. But the modern ones like SSRIs,  Effexor, Buspar, etc. are > actually quite effective and very safe in most cases. > Eric > Eric – THANKS for your thoughts on this.  I’m seeing a doctor

tomorrow.. and will probably go on meds (much better informed than last time I checked on it). Dennis  (tried to email you directly… no luck) – Hide quoted text — Show quoted text -> Steroids caused my depression…prednisone should be used conservatively > http://groups.yahoo.com/group/FactsAndFallaciesOfDepression > MIBS (Minimally Invasive Brain Stimulation) > http://www.musc.edu/psychiatry/fnrd/tms.htm

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Question:

Does anyone know of / have any experience with drugs that suppress REM sleep? I know I fall into the category of those depressed who benefit from sleep deprivation. Sleeping less usually guarantees a happier, more centered and energetic mood the next day for me. I understand from the last time I poked around in medline that it’s the reduction in REM sleep that is thought to be therapeutic, and not necessarily sleep as a whole. I’ve gone through various SSRI’s (now on sertraline) and they didn’t have a noticeable difference on my mood. If anything they made me more lethargic. I’ve tried changing my sleeping patterns but the problem is that when waking up at the hour I want to it just seems insurmountable to get out of bed. I end up laying there and then waking up 4 hours later, feeling drained. Things that screw with sleeping patterns (i.e. alcohol) typically have a positive benefit on my mood the day after. Sleeping more usually leaves me feeling worse. If anyone can offer any help, insight or experience, I’d appreciate it. Thanks.

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I’m taking 40mgs daily of Paxil, which made me very sleepy, so I started to take Mirapex, a Parkinson’s drug that is only being used recently to treat depression. I started on .25 mgs daily, went up to .5, then .75, then 1. The more I took, the more it lessened the effect of Paxil, but the more energy I had. When I hit .75 and 1 mgs a day, I was sleeping about 4 hours a night and was less tired, but my anxiety came back. I also had nightmares. I took Wellbutrin SR for a week, and I was sleeping 6 hours a night and had more energy. KC

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Question:

Did anyone here experience a flattening of emotions with Zoloft and did it get better with continued use so you were able to feel happiness after it?  What they call Flat Affect (not effect) in medical terminology?  Neither happy nor really sad, just kind of numb? H.

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yeah i did,  all the anti-depressants kill my emotions. ive never had it get any better with time. – Hide quoted text — Show quoted text ->Did anyone here experience a flattening of emotions with Zoloft and did it get >better with continued use so you were able to feel happiness after it?  What >they call Flat Affect (not effect) in medical terminology?  Neither happy nor >really sad, just kind of numb? >H.

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I started taking Zoloft a few months ago and I didn’t notice a flat affect with it.   Before that, I took Paxil for about 8 years with no flat affect noticed. Christine

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With me it did cause some flattening-but in my case that was good as my emotional turmoil had worn me out….now that I supplement with the Wellbutrin I feel more like me, but still able to function well…. bunnyfire – Hide quoted text — Show quoted text ->>Did anyone here experience a flattening of emotions with Zoloft and did it >  get >>better with continued use so you were able to feel happiness after it?  What >>they call Flat Affect (not effect) in medical terminology?  Neither happy >  nor >>really sad, just kind of numb? >>H. > I notice the opposite with SSRIs like Zoloft. Im more "flat" off meds because I > become more depressed. Severe depression causes "flatness." Numbness, > nothingness, inability to "feel" emotions, whatever youd like to call it. Go on > an SSRI and some of that ability to feel emotion comes back. Least thats been > my personal experiences. > Eric > Steroids caused my depression…prednisone should be used conservatively > http://groups.yahoo.com/group/FactsAndFallaciesOfDepression > MIBS (Minimally Invasive Brain Stimulation) > http://www.musc.edu/psychiatry/fnrd/tms.htm

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> Did anyone here experience a flattening of emotions with Zoloft and did it get > better with continued use so you were able to feel happiness after it? What > they call Flat Affect (not effect) in medical terminology?  Neither happy nor > really sad, just kind of numb? > H. > I noticed a little flattening of emotion,,,but got better after a few

months.  I have been off and on Zoloft a few times….It works really well if I give it a chance…..a foot note….I could not orgasim the first month on it…..but that went away. "FORGET ABOUT IT"

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Question:

This is my medical history: back in 1994 to 1996, I was on and off Prozac three times. The first time was because I’d been depressed for a long time, from age 16 to about 25. It worked great, it really turned me around. The second and third time was to help me get through stressful situations I was in. It helped those times too, just not as quickly or as noticeably as the first. I was med-free for 1997, 1998, and 1999 and was doing OK. In May 2000 I crashed. It was anxiety more than depression though. I tried Prozac for the fourth time and it didn’t seem to help. During a brief hospital stay I switched to Effexor, and it helped alleviate the depression, but made me sleepy. My psychiatrist added Wellbutrin last winter, and I didn’t feel cured, but I was functioning OK. The Effexor was still making me sleepy, so I replaced it with Celexa. First 20mg/day, now 30mg/day. I’d been on Celexa for 11 weeks now along with 100mg/day wellbutrin. My depresion has gotten worse over the last few weeks. I use Clonazepam a few times a week when the anxiety gets rough, which seems to be getting worse. I’m anxious all the time, I feel kind of out of breath, I feel my heart pounding sometimes, I sleep a lot, feel sad, and cry more often. My psychiatrist doubts that Celexa is making me more depressed, but I’m not so sure. I’m looking for a little advice here. Should I withdraw from Celexa and Wellbutrin and cleanse my system and start over somehow? I really miss how Prozac helped me the first three times, and maybe I could go back to it, but I’m afraid my system has become immune to it somehow. Why isn’t the celexa helping at all? Should I try another SSRI or am I now immune to all SSRIs? Dammit dammit dammit I hate this. What should I do? Michael.

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- Hide quoted text — Show quoted text – > This is my medical history: back in 1994 to 1996, I was on and off Prozac > three times. The first time was because I’d been depressed for a long time, > from age 16 to about 25. It worked great, it really turned me around. The > second and third time was to help me get through stressful situations I was > in. It helped those times too, just not as quickly or as noticeably as the > first. > I was med-free for 1997, 1998, and 1999 and was doing OK. > In May 2000 I crashed. It was anxiety more than depression though. I tried > Prozac for the fourth time and it didn’t seem to help. During a brief > hospital stay I switched to Effexor, and it helped alleviate the depression, > but made me sleepy. My psychiatrist added Wellbutrin last winter, and I > didn’t feel cured, but I was functioning OK. > The Effexor was still making me sleepy, so I replaced it with Celexa. First > 20mg/day, now 30mg/day. I’d been on Celexa for 11 weeks now along with > 100mg/day wellbutrin. My depresion has gotten worse over the last few weeks. > I use Clonazepam a few times a week when the anxiety gets rough, which seems > to be getting worse. > I’m anxious all the time, I feel kind of out of breath, I feel my heart > pounding sometimes, I sleep a lot, feel sad, and cry more often. My > psychiatrist doubts that Celexa is making me more depressed, but I’m not so > sure. > I’m looking for a little advice here. Should I withdraw from Celexa and > Wellbutrin and cleanse my system and start over somehow? I really miss how > Prozac helped me the first three times, and maybe I could go back to it, but > I’m afraid my system has become immune to it somehow. Why isn’t the celexa > helping at all? Should I try another SSRI or am I now immune to all SSRIs? > Dammit dammit dammit I hate this. What should I do? > Michael.

Hi Michael,  I’ve been on Prozac 4 different times, always coming back to it because it seemed to work the best. The way my pdoc explained it was that my brain became "bored" with the Prozac, and it didn’t work. It seem to give me a different "feel" each time I took it.  I’m not offering this as medical advice, only what *I* would do in your situation. Since the Celexa isn’t working after this long and the dose of Wellbutrin isn’t terribly high, I’d get an appointment ASAP and request another med, something "like prozac" (another SSRI like Zoloft or Paxil). When Prozac petered out on me, I started Wellbutrin and Zoloft, and feel excellant. I think it’s more or less trial and error, but don’t wait too long, your Celexa should have kicked in by now. I don’t know if your immune to SSRI’s, but Prozac died on me, and another worked fine. I’ve had many anti-depressants that may have well just been sugar pills because they did nothing, so don’t feel it’s just you. Good Luck, Dave —

Question:

I’ve been on most of the ssris over the years, and they don’t work for me. The best has been the ol’ tricyclic desipramine, but I feel I’d like to try something different. Can those of you who have had success with Serzone give me some feedback? I tried one tablet of it about 4 years ago. I took it right away when I got home from the pharmacy (as per doc) and found myself feeling like I was looking at the world through the wrong end of a telescope. I never took another tablet. In retrospect, perhaps it would have been a good med for me if I had ramped up carefully and taken it at bedtime. I think I read someone say that it helped them think more clearly. I could use that. I also have a lot of problems with insomnia. Any positive news? Also, does it cause a lot of weight gain? If you’re going to go on a tirade against ADs, just save it. I’ve heard it all.

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I had been using Wellbutrin when I changed over to Serzone.  The 2 Wellbutrin daily had made me feel kind of like I had coffee jitters. I started with 50 mg Serzone in the evening, then 50mg AM and PM, then 100mg AM and PM.  After a week, I found that I was less anxious and distracted, so I could think more clearly.  I currently take 1 Welltrin AM, and 1 Serzone PM.  I take a second Serzone at times of greater stress.  I have regained weight I lost, but I don’t think it’s the fault of Serzone.  I never had the feeling you described from Serzone, so it’s possible it won’t work,  but it wouldn’t hurt to give it a better try. As for needing to think clearly, that is really the primary difficulty with depression.  Disconnection.  From yourself.  The only real solution I’ve found to that decrease in mental energy, is to drastically simplify my life. And as I improve it gets increasingly irritating to see the things I want to do and not have the energy to do them. Christina

– Hide quoted text — Show quoted text -> I’ve been on most of the ssris over the years, and they don’t work for me. The > best has been the ol’ tricyclic desipramine, but I feel I’d like to try > something different. Can those of you who have had success with Serzone give me > some feedback? I tried one tablet of it about 4 years ago. I took it right away > when I got home from the pharmacy (as per doc) and found myself feeling like I > was looking at the world through the wrong end of a telescope. I never took > another tablet. In retrospect, perhaps it would have been a good med for me if > I had ramped up carefully and taken it at bedtime. I think I read someone say > that it helped them think more clearly. I could use that. I also have a lot of > problems with insomnia. Any positive news? Also, does it cause a lot of weight > gain? If you’re going to go on a tirade against ADs, just save it. I’ve heard > it all.

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Thank you, Christine, for your thoughtful reply. Mike in L.A.

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I was on it from mid-December until mid-April.  It affected my memory and ability to carry on a conversation (knew what I wanted to say but couldn’t utter the words) that it made me more depressed than necessary.  I also gained weight.   I’m back on Celexa (which originally caused my weight gain and sexual disinterest) but at least I can function at my job. Lori

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x-archive-no: yes i started serzone on a 1/4 dosage, once at night. have only taken it for 2 nights, but it is keeping me awake most of the night. is this normal? is it all part of the "adjustment" i have to go through to get used to this med? anyone have the same experience? i’m very sensitive to meds and also very small, so my pdoc suggested 50mg at night to start. i don’t want to sound foolish since i’ve only taken it for 2 nights so far, but missing all this sleep is getting to me already. also, last night when it kept me awake i was crying for no apparent reason, and feeling very restless. first night, i took it an hour or so before bed, and couldn’t get to sleep. second night i decided to wait till i was real sleepy before i took it, then took it, fell asleep, and woke up unable to get back to sleep. just for the record, this is not a normal pattern for me.

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It’s not normal not to sleep from Serzone.  I know!  I took it for 10 months then tried going without it and doing counselling therapy.  I managed quite well but had a relapse recently.  When I was put back on Serzone I was sleepless and manic, very agitated.  As it turns out I have a thyroid problem so I don’t know if that made the Serzone ineffective. I’m also told going back on a medication a second time can render it ineffective.  Also, if you’re bipolar, an antidepressant can reportedly "uncover" the mania.  Don’t ignore your body’s response – go see your doctor! kevin  :) Be well.

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When ever I try a new AD I try in in the morning first.  I just started serzone a week and a half ago.  I started off taking it in the middle of the day.  It makes me just a little sleepy, but nothing unbearable. I started off at 100mg and am now at 200mg.  This may be a mistake because of the danger that lies in AD’s for me. The rapid cycling and mixed states could actually kill me.  Do you tend to have an extreme reaction to AD’s?  Like rapid cycling or mixed states?  That could cause the crying, but it could also be tiredness or depression (the reason for starting the med to beggining with). Julz – Hide quoted text — Show quoted text -> i started serzone on a 1/4 dosage, once at night. have only taken it for 2 > nights, but it is keeping me awake most of the night. is this normal? is it > all part of the "adjustment" i have to go through to get used to this med? > anyone have the same experience? i’m very sensitive to meds and also very > small, so my pdoc suggested 50mg at night to start. i don’t want to sound > foolish since i’ve only taken it for 2 nights so far, but missing all this > sleep is getting to me already. also, last night when it kept me awake i was > crying for no apparent reason, and feeling very restless. > first night, i took it an hour or so before bed, and couldn’t get to sleep. > second night i decided to wait till i was real sleepy before i took it, then > took it, fell asleep, and woke up unable to get back to sleep. just for the > record, this is not a normal pattern for me.

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I used to take serzone at night and it either kept me up or woke me up after a couple of hours. The drug seems to "wire" me for about 2-3 hours and then make me drowsy. Currently I am taking it with dinner about 4 hours before bed. This has greatly improved my sleep. I now fall asleep easily and stay asleep. Eric – Hide quoted text — Show quoted text -> x-archive-no: yes > i started serzone on a 1/4 dosage, once at night. have only taken it for 2 > nights, but it is keeping me awake most of the night. is this normal? is it > all part of the "adjustment" i have to go through to get used to this med? > anyone have the same experience? i’m very sensitive to meds and also very > small, so my pdoc suggested 50mg at night to start. i don’t want to sound > foolish since i’ve only taken it for 2 nights so far, but missing all this > sleep is getting to me already. also, last night when it kept me awake i was > crying for no apparent reason, and feeling very restless. > first night, i took it an hour or so before bed, and couldn’t get to sleep. > second night i decided to wait till i was real sleepy before i took it, then > took it, fell asleep, and woke up unable to get back to sleep. just for the > record, this is not a normal pattern for me.

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x-archive-no: yes thanks, eric… i’m going to try this suggestion tonight. had another sleepless and agitated night last night. if this doesn’t work, well, it’s back to the pdoc to work something else out. – Hide quoted text — Show quoted text – >I used to take serzone at night and it either kept me up or woke me up >after a couple of hours. The drug seems to "wire" me for about 2-3 hours >and then make me drowsy. Currently I am taking it with dinner about 4 >hours before bed. This has greatly improved my sleep. I now fall asleep >easily and stay asleep. >Eric

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