Question:

Anybody tried sibutramine (Meridia, the so-called weight loss drug) as an antidepressant? How did it fare in comparison to other ADs (Effexor and Effexor XR in particular)? I heard some peculiar claims about it recently, is why I was asking. -elizabeth

Response:

 > Meridia doesnt specifically increase neurotransmitters in the  > brain like ADs do. Rather they increase them everywhere  > in the body Not so, all ADs do whatever they do everywhere in the body.  For example, platelets (in blood) have a serotonin transporter, and all of the SSRIs block the reuptake of serotonin into platelets.  In fact, platelets are often used in the lab to measure things involving the serotonin transporter. Meridia