Question:

My pdoc just started me on provigil for boost of energy to help me not sleep 24/7 like usual.  I did a google search on it, and saw a couple posts about an interaction between it and my current ssri celexa. One post said that they are both metabolized by the same pathway (2c19?) which causes an interaction. Another post said that in clinical trials, those also on celexa did not benefit from the provigil like those on other ssris did. Anyone know if this could be true?

Response:

I took Provigil for a year whilst on Prozac 40mg.  No interaction to speak of–although my liver enzymes became a bit elevated–check yours after being on it for some months. It worked all right for me–but its antisleepiness effects didn’t last very long ( about three hours).

– Hide quoted text — Show quoted text -> My pdoc just started me on provigil for boost of energy to help me not > sleep 24/7 like usual.  I did a google search on it, and saw a couple > posts about an interaction between it and my current ssri celexa. One > post said that they are both metabolized by the same pathway (2c19?) > which causes an interaction. Another post said that in clinical trials, > those also on celexa did not benefit from the provigil like those on > other ssris did. Anyone know if this could be true?

Response: