Question:

A few days ago I started taking CELEXA to treat depression.  For the past several years I have been taking about 25 tablets of Dramine everyday.  I am not concerned with the side effects.  I am worried that this will prevent the Celexa from working.  Does anyone know/

Response:

There have been no studies about the effects of diphenhydramine and caffeine, the major metabolites of dimenhydrinate, and citalopram. Metabolic drug interactions can cause blood levels of either drug to be lowered or raised. These three drugs work on different receptors in the brain, so theoretically there should not be problems in that area. As a curious and nosy person, may I inquire as to why you take 20 tablets of dimenhydrinate daily, and what effect it has on you.

– Hide quoted text — Show quoted text -> A few days ago I started taking CELEXA to treat depression.  For the past > several years I have been taking about 25 tablets of Dramine everyday.  I am > not concerned with the side effects.  I am worried that this will prevent > the Celexa from working.  Does anyone know/

Response: